GETTING MY PKRRATING TO WORK

The activated enzyme then phosphorylates its key substrate, the translational initiation issue eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to the conserved spouse and children of 4 protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to diverse stimuli12, triggering the built-in s